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BioProfile® FLEX
  • BioProfile FLEX Analyzer
  • System Integration
  • Specifications

One Automated Analyzer for Fast Comprehensive Cell Culture Analysis

BioProfile® FLEX is the first analyzer to provide a comprehensive cell culture analysis in a single, easy to use instrument.

Test menu choices include glucose, lactate, glutamine, glutamate, pH, PO2, PCO2, ammonium, sodium, potassium, ionized calcium, cell density, cell viability, cell diameter, osmolality, and IgG. Up to 16 key assays can be simultaneously analyzed from a small, 1mL sample saving valuable processing time and cost.

The Power of One

  • One Compact Workstation
  • One Intuitive, Easy to Use Operator Interface
  • One Small, 1 mL Sample
  • One Fast Analysis, as little as 2.5 minutes
  • One Consolidated Report

Modular Field Upgradeable Analysis System

chemistry and gas modulecell density and viability modulelgG module

System Integration Options

On-Line Autosampler

An automated sampling system connects up to 10 bioreactors to one BioProfile FLEX

  • Maintains a sterile barrier
  • Provides real time testing either automatically pre-scheduled or manually initiated

Advanced OPC Connectivity

Provides automated bi-directional flow of data and control commands

The Nova OPC Connectivity Suite integrates BioProfile FLEX with any OPC compliant device such as bioreactor controllers, data historians, laboratory information management systems (LIMS), and plant management systems.

  • Easy "handshake" connection to any OPC compliant device
  • Connectivity verification
  • DA and HDA OPC capability
  • Backward compatibility to all OPC versions
  • Remote monitoring of BioProfile FLEX status and data

 

Specifications

Sample Analysis Time:
 2.5 minutes (Gases only)
4.0 minutes (Chemistry/Gas & Osmolality)
6.25 minutes (All 16 tests)

Operating Temperature Range:
15-30°C (59-86°F)

Operating Relative Humidity Range:
20-85%

Sample Size:
1 mL (for all modules)

Sampling Options:
Individual via syringe/cup
Automated batch using 20-position sampling tray
On-line, automated from up to ten bioreactors

Host Computer Operating System:
Windows XP

Electrical Requirements:
90-264 VAC, 50 to 60 Hz (Universal Power Supply)

System Size:
Height: 20 in (50 cm)
Width: 26 in (66 cm)
Depth: 20 in (50 cm)

System Weight:
Analyzer: 94 lbs (42.6 kg) without reagents
Host Computer Monitor/CPU: 41.5 lbs (18.8 kg)

Safety Certifications:
TUV: IEC 61010-1:2001

Quality Systems Certifications:
TUV: ISO9001:2000 FDA Registered Quality Compliant, PAT Compatible, 21 CFR Part 11 Compliant

On-Line Autosampler

Switch Pumping Module

Height: 8.86 inches (22.5cm)
Width: 27.4 inches (69.5cm)
Depth: 19.4 inches (49.3cm)
Weight: 35 lbs (16 kg)
Electrical requirements: 110/230 VoltAC, 50/60 Hz
Automated sampling from up to 10 bioreactors

Reactor Valve Module (RVM)

Height: 7.5 inches (19.5cm)
Width: 4 inches (10.16cm)
Depth: 5.75 inches (14.6cm)
Weight: 4 lbs (2 kg)
Electrical requirements: Supplied by Switching Pumping Module
Requires one RVM per bioreactor

Chemistry/Gas Module

Assay Measurement Range Resolution Method
Glucose 0.2–30.0 g/L* 0.01g/L Biosensor
Lactate 0.2–10.0 g/L* 0.01g/L Biosensor
Glutamine 0.2–12.0 mmol/L* 0.01 mmol/L Biosensor
Glutamine 0.2–12.0 mmol/L* 0.01 mmol/L Biosensor
Ammonium 0.2–25.0 mmol/L 0.01 mmol/L Direct ISE
pH 5.000–8.000 0.001 Direct ISE
PCO2 3.0–300.0 mmHg 0.1 mmHg Direct ISE
PO2 3.0–800.0 mmHg 0.1 mmHg Clarke Electrode
Sodium 40–220 mmol/L 0.1 mmol/L Direct ISE
Potassium 1.0–100.0 mmol/L 0.01 mmol/L Direct ISE
Calcium 0.10–10.0 mmol/L 0.01 mmol/L Direct ISE

Calculated Tests: O2 Saturation; CO2 Saturation; Temp. Corrected pH, PCO2, PO2

*Ranges Reflect User Selectable 1:2 Dilution

Osmolality Module

Assay Measurement Range Resolution Method
Osmolality 0–1500 mOsm/kg 1 mOsm/kg Freezing Point

Cell Density/Viability Module

Assay Measurement Range Resolution Method
Cell Diameter 4 – 50 μm N/A Digital Imaging
Detectable Density 50,000 - 100,000,000 cells/mL** N/A Digital Imaging
Viability 0 – 100% N/A Digital Imaging

**Ranges Reflect User Selectable 1:2, 1:4, 1:5, 1:10 Dilution

IgG Module

Measurement Range: 0.10–5.00 g/L*

*Ranges Reflect User Selectable 1:2 Dilution