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#141: Monitoring Magnesium to Guide Magnesium Therapy for Heart Surgery
(T. Shirey, Ph.D., J. Anesth, Vol. 18, 5/04) For many years it has been recognized that magnesium levels play an important role in morbidity associated with heart surgery. However, considerable confusion exists in the literature whether Mg should be administered to these patients and, if so, how much and when. This article reviews methods to evaluate Mg status in patients, causes and consequences of abnormal Mg levels perioperatively, outcome improvements and risks with Mg supplementation, and guidelines for administering Mg therapy. |
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#136:
Caring for the Critically Ill
(T. Shirey, Ph.D., Advance/Lab,
Vol. 12, No. 9, 9/03)
With
technology available to produce a
core critical care profile from <200µL
of whole blood in less than 2 minutes,
real-time therapy is becoming a reality
for the most compromised patients
where critical care profiling and
point-of-care strategies are used. |
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#124:
Speaking Out on Point-of-Care (POC)
Testing and POC Connectivity
(J. DuBois, Ph.D., MEEN Cardiology-Critical
Care Tech, Vol. 41, No. 5, 9-10/01)
As
hospitals are moving toward greater
use of point-of-care devices, the
need for rapid data transfer from
these analyzers to and from the laboratory
has heightened to the point where
direct electronic connectivity methods
are essential. |
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#123:
Remote Access Automated Order Entry,
Specimen Accessioning, Test Order
Creation, and Data Capture for Point-of-Service
Testing in Critical Care Units
(J. DuBois, JALA,
Vol. 4, No 3, 7/99)
This
technical report describes an automated
process adopted by a large university
medical center to support decentralized
testing at the point of service in
the Departments of Pediatrics and
Emergency Medicine. |
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#121:
Getting to the point: Integrating
critical care tests in the patient
care setting
(J. DuBois, Ph.D. C(ASCP)SC,
MLO, 6/00)
Implementing
testing services in the patient care
setting offers the lab manager many
challenges. At this hospital system,
an innovative data management solution
addressed the problems of a simple
user interface, automatic creation
of test orders and accession numbers,
remote review of test results by the
central laboratory, and an interface
to the LIS and HIS for complete data
capture. |
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#117:
Case Study: Point of Care Testing
Getting to the Heart of the Matter
(E. Szelag, MHM, BS,
MT(ASCP) and H. Polishook, Advance
for the Lab, Vol. 10, No 6, 6/01)
As
emphasis on point-of-care testing
expands at major US hospitals, POC
Coordinators have taken on greater
responsibilities, including implementation
of multiple testing apparatus and
multiple testing locations, expanded
menus, regulatory compliance, training
and competency, quality control, and
data capture. Along with the increase
in remote testing has been a significant
increase in the tests ordered by the
physician. In order to keep pace with
these trends, the POC Coordinator
must have the appropriate instrumentation
and management tools at his or her
disposal.
This
case study describes how Holmes Regional
Medical Center instituted a comprehensive
point-of-care testing program to respond
to the increased demands of their
new Open Heart Institute. |
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#115:
Multicenter study of whole blood creatinine,
total carbon dioxide content, and
chemistry profiling for laboratory
and point-of-care testing in critical
care in the United States
(G. Kost, M.D. Ph.D.
et al, Univ. of CA, Davis, Crit Care
Med 2000, Vol. 28, No 7, 7/00)
Multicenter
sites compared whole blood measurements
with a transportable analyzer (Nova
16, Nova Biomedical) to assess its
potential for point-of-care testing
versus plasma measurements from the
same specimens with local reference
instruments. |
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#113:
Measuring ionized magnesium in complex
physiological solutions
(H. Polishook, Nova Biomedical,
Am Clin Lab, Vol. 19, No 11, 11-12/00)
Magnesium
is the fourth most abundant cation
in the human body, and the second
most common intracellular cation after
potassium. A co-factor for more than
325 cellular enzymes, magnesium can
play a pivotal role in such functions
as control of neuronal activity, cardiac
excitability, neuromuscular transmission,
vasomotor tone, and blood pressure.
The
purpose of this article is to discuss
why measurement of ionized magnesium
(iMg) can provide a more clinically
significant result than total magnesium
(TMg), and to support the use of an
ion-selective electrode based instrument
to achieve the most accurate test
profile. |
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#102:
Importance and Interpretation of Ionized
Magnesium (iMg) Activity in Acutely
and Chronically Ill Patients
(T. Shirey, Ph.D., Nova Biomedical,
2/00)
Abnormal
blood magnesium (Mg) activity can
have profound effects in either acutely
or chronically ill patients, and it
is the physiologically active fraction
of total magnesium (TMg). Ionized
magnesium does not always correlate
to TMg and is often an easier assay
and better physiological indicator
of the clinical need for magnesium
supplementation.
This
review examines several physiologic
systems relying on Mg activity; how
whole blood plasma iMg serves as a
relevant indicator of Mg status; what
factors affect iMg activity; and why
detection and real time management
of Mg abnormalities can provide better
patient outcomes in a variety of acute
and chronic clinical settings. Cites
550 specific references. |
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#101:
Maximizing POCT with Innovative Data
Management
(I. Kampa, Ph.D., The
Valley Hospital, Ridgewood, NJ, Advance
for the Lab, Vol. 9, No 2, 2/00)
Clinical
laboratories are under constant pressure
to provide testing at or near critically
ill patients in order to provide the
shortest possible turnaround times.
This
article describes how The Valley Hospital
established a point-of-care testing
program without increasing laboratory
staffing and without the typically
high cost of POC devices and reagents. |
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#100:
A Cost Effective High Performance Approach
to Critical Care Testing
(Lab Med, Vol. 30, No 9,
9/99) |
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#90:
Automated Order Entry Accessioning,
Test Order Creation, and Data Capture
for Point-of-Service Testing with Nova
Biomedical Patient Data Manager
(J. DuBois, Ph.D. et al,
Univ. Hosp. Health Syst Cleveland, 2/99) |
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#73:
Evolution of Blood Chemistry Analyzers
Based on Ion Selective Electrodes
(C.C. Young, Ph.D., Waters
Symposium, J of Chem Ed, Vol. 74,
No 2, 2/97) |
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#62:
Cord Lactate, pH, and Blood Gases
from Healthy Neonates
(T. Shirey, Ph.D. at al, Gyn and
Obst Invest, Vol. 41, 1996) |
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#60:
Critical Care Profile Testing for
Informed Treatment of Severely Ill
Patients
(T. Shirey, Ph.D. 9/95) |
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#59:
Understanding Blood Lactate Analysis
(J.
Kruse, M.D., J Resp Care Pract, 8-9/95) |
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#58:
Cost Analysis of Point-of-Care Laboratory
Testing in a Community Hospital
(Am J Clin Path, 2/95) |
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#55:
Magnesium in Cardiovascular Biology
(B.M.
Altura and B.T. Altura, Sci Am, 5-6/95) |
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#54:
Point-of-Care Testing: An Approach
that Stimulates New Thinking
(T.
Dilts, MT(ASCP), MBPA, 2/95) |
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#53:
Deficiency in Serum Ionized Magnesium
But Not Total Magnesium in Patients
With Migraines. Possible Role of iCa2+/iMg2+
Ratio
(A. Mauskop et al, Headache, Vol.
33, No 3, 3/93) |
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#52:
Talking About Technology, Medical Automation
Systems’ RALS
(H. Kisner, Clin Lab Mgmt Assoc,
Inc., 1995) |
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#41:
Point-of-Care Testing – Meeting
Regulatory Guidelines with Nonlaboratory
Personnel
(N. St. John and R. Reed, 1994) |
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#40:
Minimizing Admission Laboratory Testing
in Trauma Patients: Use of a Microanalyzer
(Frankel et al, J Trauma, Vol. 37,
No 5,1994) |
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#39:
The Use and Clinical Importance of a
Substrate-Specific Electrode for Rapid
Determination of Blood Lactate Concentrations
(Auden et al, JAMA, Vol. 272, No
21, 12/7/94) |
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#36:
Unique Magnesium-Sensitive Ion Electrodes
(B.M. Altura and A. Lewenstam, The
Scandanavian J Clin and Lab Investigation,
Vol. 54, Suppl 217, 1994) |
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#35:
Ionized Magnesium: A New Assay
(T. Shirey, Ph.D., Clin Chem News,
Vol. 19, No 5, 5/93) |
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#33:
When Time Equals Lives, Nova Wins
(Helix, Univ of Virginia Sciences
Quarterly, Spring, 1992) |
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#32:
A Clinical Review of Ionized Calcium.
A Better Indicator than Total Calcium
(J. Toffaletti, Ph.D., 1992) |
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#29:
Bedside Diagnostic Blood Testing, Its
Accuracy, Rapidity, and Utility in Blood
Conservation
(M. Salem, M.D, et al, JAMA, Vol.
266, No 3, 7/17/91) |
|
#27:
Hypomagnesemia is Common Following Cardiac
Surgery
(L. Aglio et al, J Cardiothorac
and Vasc Anesth, Vol. 5, No 3, 6/91) |
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#26:
The Impact of Whole Blood Testing on
Response Time
(G. Kost, M.D., Ph.D., Arch Pathol
Lab Med, Vol. 114, 1990) |
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#25:
New Whole-Blood Testing for Lab Support
of Critical Care at Cardiac Transplant
Centers and US Hospitals
(G. Kost, M.D., Ph.D. and T. Shirey,
Ph.D., Arch Pathol Lab Med, Vol. 114,
9/90) |
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#24:
Strategies of Organization and Service
for the Critical-Care Laboratory
(M. Fleisher and M. Schwartz, Clin
Chem, Vol. 36, No 8(B), 1990) |
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#23:
Electrode Measurement of Glucose and
Urea in Undiluted Samples
(Y. Gourmelin et al, Clin Chem,
Vol. 36, No 9, 1990)
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#130:
Fed-Batch Process for Mab Production
(A. Frison and K. Memmert, GEN,
Vol. 22, No. 11, 6/1/02)
The
authors describe a cost-effective
fed-batch process for large-scale
production of monoclonal antibodies
(Mabs) incorporating the BioProfile
200 Chemistry Analyzer to monitor
the full range of analytes available
on the system. |
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#111:
Analytical Studies of Four Mammalian
Cell Lines Using the BioProfile 200
(D. Wyatt et al, Kansas
University, 6/00)
Significant
aspects of the metabolism of four
cell lines in stationary culture were
studied using the Nova BioProfile
Chemistry Analyzer. |
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#106:
Rapid Monitoring of Mammalian Cell
Culture
(H. Polishook, GEN, 3/00)
While
the biotechnology industry generally
utilizes fundamental scientific principles
in its day-to-day operations, cell
culture is frequently approached as
more art than science. In cell culture,
there is often a lack of adequate
on- or off-line data to correlate
with culture performance or product
quality.
This article focuses on mammalian
cell culture and the key biochemical
parameters that should be monitored,
including introduction of an advanced
instrument (BioProfile Chemistry Analyzer,
Nova Biomedical) that allows rapid,
real-time monitoring of these parameters. |
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#89:
An Improved Method for Rapid Monitoring
of Cell Culture and Fermentation Processes
(C. Quern, ABL, 12/98) |
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